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Artistic originality here is likened to the murderer of convention.
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It's originality that destroys convention,
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and here it's given that frisson of being a criminal too.
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He's suggesting the criminality of real artistic innovation,
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and by doing that, by using that language to describe
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artistic originality, he allies artistic originality with the figure of Humbert.
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So, there are multiple ways, at multiple levels,
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that Nabokov is defending his work in this afterword.
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For one thing, he insults the publishers.
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He suggests that they didn't finish the manuscript because,
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when his manuscript turned out not to be pornographic genre fiction,
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they stopped reading, 'cause that's what they wanted,