来自《耶鲁大学开放课程：生物医学工程探索 第24集 第24集》

• 
  
  signaling molecules called tyrosine kinases
  酪氨酸激酶的信号分子
• 
  
  were to creating intracellular signals.
  在产生胞内信号是如何的重要
• 
  
  Well, it turns out that certain kinds of tumors
  研究发现特定种类的肿瘤
• 
  
  you use a special tyrosine kinase called BCRABL
  使用称为BCRABL的特殊酪氨酸激酶
• 
  
  and that that tyrosine kinase can be inhibited by a drug
  这种激活酶可以被一种专门设计
• 
  
  that was designed to inhibit it, called Gleevec.
  来抑制该酶的药物所抑制 该药名为格列卫
• 
  
  Now, this is one of the first examples of
  现在这是理性药物设计的
• 
  
  what's called rational drug design,
  第一个例子
• 
  
  in that biologists have
  生物学家已经
• 
  
  identified this particular tyrosine kinase.
  鉴定出这种特别的酪氨酸激酶
• 
  
  They knew it was involved in
  他们已经知道它涉及
• 
  
  signaling inside certain kinds of cancers,
  某些特定癌细胞内的信号