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and are highly infective and
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important in the spread of the disease by fomites.
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At this point,
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the fluid portion of the pustule is absorbed,
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leaving behind the solid part.
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Large areas of the skin may begin to peel off,
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leaving deeper tissues raw and exposed.
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These areas are all painful, and contribute to the
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frightening appearance and the misery of the patient.
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Fatal cases often occurred from about the eighth day,
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and an important reason was toxemia, because these lesions
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were susceptible to infection.