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because of the frequency of their mutations,
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and the extremely brief length of a microbial generation,
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compared with a human one.
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So, new diseases have always been emerging and appearing.
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And Asiatic cholera is a good example of what we might--
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though let's be mindful, it would be historically anachronistic--
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we might call it a great emerging disease of the nineteenth century.
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There is a scholarly debate on whether cholera had long existed
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on the Indian subcontinent,
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and whether it went back for centuries or not.
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It clearly, by the early nineteenth century,
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had an endemic home on the Indian subcontinent,