-
and these are the biological mechanisms that are involved here
-
and only shown by orange arrows on this slide.
-
The end result is
-
you can design now very specific
-
double stranded RNA sequences,
-
that when delivered into cells again will activate this process of
-
natural degradation of an existing messenger RNA.
-
Of course,
-
if you degrade the messenger RNA at a rapid rate
-
then you'll stop expression of the cells.
-
Now the nice thing about this is that the degradation mechanisms seem to persist for some period of time,
-
beyond the time at which you deliver the double stranded RNA; whereas,