来自《耶鲁大学开放课程：生物医学工程探索 第4集 第4集》

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  Well one way you could do it is by saying
  一种方法是通过考虑
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  'if I have this one base pair difference
  "如果我有这个不同的碱基对
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  then this sequence is going to be
  那该序列必然会
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  cut by a specific
  被特定的限制酶识别并切割
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  restriction enzyme that recognizes the sequence
  这个特定的限制酶能识别
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  That restriction enzyme, there is a restriction enzyme that does that and it's MST-3.
  确实存在这种限制酶 叫MST-3
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  If I took this same restriction enzyme and
  而如果我用同样的限制酶
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  tried to cut the chromosomal DNA of a sickle patient,
  去切割病人的染色体DNA
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  it wouldn't cut at that point
  那该酶是不会起作用的
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  because the wrong sequence is there.
  因为基因序列不对
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  Here's - how can I find that, right?
  那我该如何找到它呢
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  Here's the difference between normal hemoglobin
  正常血红蛋白和镰状红细胞贫血的