-
although it was present in Europe during the Crusades,
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the conditions at that time
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led to its beginning
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to have a more important impact,
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that reached its highpoint
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in the late-seventeenth and then throughout the eighteenth century.
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And that had to do with preconditions that enabled it to flourish,
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preconditions associated with industrial development,
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the commercialization of agriculture,
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and rapid, unplanned urbanization.
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In the eighteenth century,
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smallpox had clearly replaced plague