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lifelong immunity to this disease was important.
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No one was naturally infected twice with smallpox.
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So, a typical pattern emerged in the cities of Europe,
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and that was that smallpox became an ever-present disease
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that most people who survived childhood had suffered.
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The adult population therefore possessed what we might call
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an extensive herd immunity to smallpox as a disease.
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So, it became an endemic disease of childhood.
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But at intervals,
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perhaps every generation or so,
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smallpox would erupt as a major epidemic
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among the general population.