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The Spaniards militarily dispossessed the Arawaks of their land,
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and intended to reduce them to slavery,
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first in mines and then on the land.
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They were assisted in the process, up to a point,
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by two great assets: gunpowder and disease.
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And as you know from reading Fenn, the aboriginal population
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of the Americas lacked immunity to European diseases like
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smallpox and measles.
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There's no evidence that there was a plot of genocide or
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bioterror in the intentional use of disease as a means to clear
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the land and resettle it.
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What happened was spontaneous, and not intentional.