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after a period of time,
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had a challenge in vaccination
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with live smallpox virus.
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And happily the experiment
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was a great success,
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and Edward Phipps demonstrated that he was immune,
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by this procedure, to smallpox.
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And, so, soon thereafter,
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Edward Jenner--
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whatever one thinks, by modern terms,
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of the medical ethics of that particular experiment--
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in 1798 Edward Jenner wrote