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There was the opposition of liberals and libertarians to
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what they regarded as the excessive power of the state in
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making vaccination compulsory.
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And there was religious opposition,
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people who considered it an act of impiety to introduce material
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from animals into a human body, and there were sardonic posters
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featuring people undergoing vaccination while they sprouted
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horns or turned into cows.
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But despite vaccination, there was, in Britain,
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an Act of 1840 that
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provided for free infant vaccination.
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And from that time, the annual toll from smallpox