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When positrons are emitted,
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they will move through tissue until they hit an electron.
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Positrons don't have to move very far,
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there's lots of electrons around in tissues.
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When a positron hits an electron,
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they annihilate one another and they generate two gamma rays
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which move in opposite directions.
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If I have a positron emitting substance in the brain,
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it will emit gamma rays which can be detected.
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Because I'm detecting one here
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and one here,
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I know exactly where the source came from.