来自《耶鲁大学开放课程：生物医学工程探索 第10集 第10集》
-
to make a substance that looks like a vaccine--以便制造出一种类似疫苗 -
looks like a virus but can't replicate.应该是类似病毒但却无法进行复制的物质 -
We talked about attenuating in the laboratory,我们讲过实验室中 -
using cell culture techniques利用细胞培养技术培养减毒疫苗 -
and what we know about mutating viruses.以及我们所了解的减毒病毒 -
One can also purify parts of the protein,人们还可以纯化部分蛋白质 -
that is, parts of the virus,也就是病毒的某些部分来制造疫苗 -
that is, "Do I really need to deliver the whole virus?"那么还需要接种完整的病毒吗 -
If the immune system recognizes only small pieces of the virus如果免疫系统识别出病毒的一小段 -
and mounts an immune response to that,就可以诱发起免疫应答 -
how about if I just take these pieces of a virus那么如果我仅用一小部分病毒 -
like some structural subunit, some piece of protein比如一些结构性亚基 一些蛋白质的片段