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But if you had either one short allele or two short alleles
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and you were confronted with maltreatment as a child,
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you had a much greater probability of becoming depressed
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at some time in your life. And this has been replicated with other samples,
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with other forms of major trauma. And basically the story is,
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it takes the intersection of a genetic predisposition
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and major stress to create full-blown depression in some people.
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Now, that may not be true for all genetic predispositions
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or all forms of depression, but this serotonin finding has actually
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been replicated now in at least four different studies。
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So, it seems to be a pretty reliable effect。
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So again, genes do not determine the disorder, but the intersection of genes