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The hippocampus is an area of the brain
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that's very involved in memory and in concentration.
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And in people with chronic depression,
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you often see shrinkage in the hippocampus,
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and this may be related to their problems in concentration and attention.
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And then finally, the anterior cingulate is an area of the brain
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that's involved in a lot of different activities,
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but pertinent to the mood disorders,
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particularly in responses to distress--to stress
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and in sort of the choice of behaviors.
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And it may be that dysregulation of the anterior cingulate may be involved
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in the person's difficulty in responding appropriately to stress,