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Remember that picture I showed you several weeks ago?
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Because of that for a molecule to enter
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it has to be able to go through that monolayer of cells.
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Even if insulin wasn't broken down to its constituent molecules
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it couldn't be absorbed very easily because it's a large molecule.
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Only molecules that are small and relatively lipid soluble
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can go through monolayers of cells like the epithelium of the intestine.
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There's two reasons why insulin is not very bioavailable
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when it's given orally.
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That's one way of saying insulin doesn't end up in the blood,
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insulin is not bioavailable when delivered orally.
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Some drugs are aspirin, acetaminophen, Ibuprofen,