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The first was by Patrick Manson in 1883.
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At that time, he discovered something that was radically new.
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He was dealing with the disease of elephantiasis,
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and he found that the filarial worm that causes it
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is transmitted by mosquitoes;
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the first example of a vector borne disease transmission.
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This was epoch-making in that respect.
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And it was also a movement from bacteria or--
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though it wasn't known at the time--
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viruses, to more complex life forms,
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the interaction of humans with biologically more sophisticated
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protozoa or helminths or worms,